A significant number of mutations in the HBB gene that cause human β-thalassemia occur within introns or in upstream noncoding sequences. Explain why mutations in these regions often lead to severe disease, although they may not directly alter the coding regions of the gene.

Hello, everyone here We have a question that says scientists have discovered approximately 400 different mutations in the h. B. B. Gene that causes beta thalassemia determine the type of mutation that occurs when the beta polyp peptide chain terminates prematurely. So it is terminating prematurely, which makes this a nonsense mutation because in it a code on changes to a stock code on. So our answer here is b nonsense mutation. Thank you for watching. Bye!