Shown below are two homologous lengths of the alpha and beta chains of human hemoglobin. Consult a genetic code dictionary (Figure 13.7), and determine how many amino acid substitutions may have occurred as a result of a single nucleotide substitution. For any that cannot occur as a result of a single change, determine the minimal mutational distance. Alpha: ala val ala his val asp asp met pro Beta: gly leu ala his leu asp asn leu lys

Everyone. Let's take a look at this question together which gene is affected by a point mutation in sickle cell hemoglobin. So let's recall what we've learned about sickle cell hemoglobin. To figure out which of the following genes is affected by a point mutation to cause that sickle cell hemoglobin. So we know that sickle cell hemoglobin is a result of a point mutation and that the condition is caused Bye. A substitution of veiling in place of glycemic asset. And so this substitution, which is that point mutation occurs in the beta globe in jean. So answer Choice B is the correct answer because a point mutation in that beta globe in gene results in the substitution of veiling for glutamine acid, leading to the production of abnormal hemoglobin in sickle cell disease. So, answer Choice B is the correct answer. I hope you found this video to be helpful. Thank you and goodbye.