Assume that a mutation affects the gene for each of the ...

Question

Assume that a mutation affects the gene for each of the following eukaryotic RNA polymerases. Match each mutation with the possible effects from the list provided. More than one effect is possible for each mutation.

RNA Polymerase Mutation Effect(s)
RNA pol I _______________
RNA pol II _______________
RNA pol III _______________
snRNA _______________

Some tRNA is not synthesized.

Accepted Answer

Hey, everyone. Let's take a look at this question together. What diseases have been linked to mutations in the R N A polymerase three gene? Is it answer choice. A hypertension and arthritis. Answer choice B hypo myelinating leukodystrophy and some forms of cancer. Answer choice. C Alzheimer's disease and Parkinson's disease or answer choice. D cystic fibrosis and sickle cell anemia. Let's work this problem out together to try to figure out which of the following diseases are linked to mutations in the R N A polymerase three gene. So we know that the R N A polymerase three gene is responsible for the transcription of small noncoding R N A s that are involved in tumor suppression as well as the cell cycle regulation. And so we are trying to determine what diseases are linked to mutations in that gene that is responsible for the transcription of those small non coding R N A S involved in tumor suppression and cell cycle regulation. Well, we can recall that a mutation in tumor suppression can lead to various forms of cancer. And researchers have also learned that mutations in the cell cycle regulation have been linked to hypo myelinating leukodystrophy, which is a rare genetic disorder that is characterized by having insufficient myelin production in the central nervous system. And so we have these mutations in tumor suppression that leads to some forms of cancer as well as the mutations in cell cycle regulation that have been linked linked to hypo myelinating leukodystrophy. So, looking at our answer, choices, we can see that answer. Choice B says hypo myelinating leukodystrophy and some forms of cancer, which are the diseases that have been linked to mutations in the R N A polymerase three gene. So answer choice B is the correct answer. I hope you found this video to be helpful. Thank you and goodbye.

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