13. Gene Regulation in Eukaryotes
Epigenetics, Chromatin Modifications, and Regulation
4: minutes
Problem 24e
Textbook Question
Textbook QuestionA particular type of anemia in humans, called β-thalassemia, results from a severe reduction or absence of the normal β-globin chain of hemoglobin. However, the γ-globin chain, normally only expressed during fetal development, can functionally substitute for β-globin. A variety of studies have explored the use of the nucleoside 5-azacytidine for the expression of γ-globin in adult patients with β-thalassemia.
Explain why this drug may also have some adverse side effects.
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