19. Cancer Genetics
Cancer Mutations
Problem 25a
Textbook Question
Textbook QuestionMutations in tumor-suppressor genes are associated with many types of cancers. In addition, epigenetic changes (such as DNA methylation) of tumor-suppressor genes are also associated with tumorigenesis [Otani et al. (2013). Expert Rev Mol Diagn 13:445–455].
How might hypermethylation of the TP53 gene promoter influence tumorigenesis?
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