15. Genomes and Genomics
Sequencing the Genome
1:51 minutes
Problem 25b
Textbook Question
Textbook QuestionWhole-exome sequencing (WES) is helping physicians diagnose a genetic condition that has defied diagnosis by traditional means. The implication here is that exons in the nuclear genome are sequenced in the hopes that, by comparison with the genomes of nonaffected individuals, a diagnosis might be revealed.
What are the strengths and weaknesses of this approach?
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