In humans, hemophilia A (OMIM 306700) is an X-linked recessive disorder that affects the gene for factor VIII protein, which is essential for blood clotting. The dominant and recessive alleles for the factor VIII gene are represented by H and h. Albinism is an autosomal recessive condition that results from mutation of the gene producing tyrosinase, an enzyme in the melanin synthesis pathway. A and a represent the tyrosinase alleles. A healthy woman named Clara (II-2), whose father (I-1) has hemophilia and whose brother (II-1) has albinism, is married to a healthy man named Charles (II-3), whose parents are healthy. Charles's brother (II-5) has hemophilia, and his sister (II-4) has albinism. The pedigree is shown below.
Determine the probability that the first child of Clara and Charles will be a
i. boy with hemophilia
ii. girl with albinism
iii. healthy girl
iv. boy with both albinism and hemophilia
v. boy with albinism
vi. girl with hemophilia <>
2. Mendel's Laws of Inheritance
Sex-Linked Genes