Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
17. Mutation, Repair, and Recombination
Induced Mutations
2:11 minutes
Problem 1a
Textbook Question
Textbook QuestionIdentify two general ways chemical mutagens can alter DNA. Give examples of these two mechanisms.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Chemical Mutagens
Chemical mutagens are substances that can cause changes in the DNA sequence of an organism. They can interact with DNA directly or indirectly, leading to mutations. Common examples include base analogs, which mimic normal DNA bases, and alkylating agents, which add alkyl groups to DNA, altering its structure and function.
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Induced Mutations
Base Substitution
Base substitution is a type of mutation where one nucleotide in the DNA sequence is replaced by another. This can lead to changes in the amino acid sequence of proteins, potentially altering their function. An example is the incorporation of a base analog during DNA replication, which can result in a permanent change in the genetic code.
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Base Distortions
Frameshift Mutation
Frameshift mutations occur when nucleotides are added or deleted from the DNA sequence, shifting the reading frame of the genetic code. This can drastically change the resulting protein, often leading to nonfunctional proteins. An example is the action of intercalating agents, which insert themselves between DNA bases, causing insertions or deletions during replication.
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Point Mutations
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