Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
17. Mutation, Repair, and Recombination
Types of Mutations
2:24 minutes
Problem 1a
Textbook Question
Textbook QuestionIdentify the normal functions of the following genes whose mutations are associated with the development of cancer.
c-MYC (Burkitt lymphoma)
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
c-MYC Gene Function
The c-MYC gene is a proto-oncogene that encodes a transcription factor involved in cell cycle regulation, apoptosis, and cellular growth. It plays a crucial role in promoting cell proliferation and is essential for normal cellular functions. When mutated or overexpressed, c-MYC can lead to uncontrolled cell division, contributing to cancer development, such as in Burkitt lymphoma.
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08:26
Functional Genomics
Proto-oncogenes and Oncogenes
Proto-oncogenes are normal genes that, when mutated or abnormally expressed, can become oncogenes, leading to cancer. They typically promote cell growth and division. Understanding the transition from proto-oncogene to oncogene is vital in cancer biology, as it highlights how genetic alterations can disrupt normal cellular processes and lead to malignancies.
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Cancer Mutations
Burkitt Lymphoma
Burkitt lymphoma is a type of non-Hodgkin lymphoma characterized by the rapid growth of tumors, often associated with the c-MYC gene's translocation. This cancer is linked to the overexpression of c-MYC due to chromosomal rearrangements, which leads to increased cell proliferation. Recognizing the relationship between c-MYC mutations and Burkitt lymphoma is essential for understanding the genetic basis of this cancer.
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