Shown here are the amino acid sequences of the wild-type...

Question

Shown here are the amino acid sequences of the wild-type and three mutant forms of a short protein.
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Wild-type: Met-Trp-Tyr-Arg-Gly-Ser-Pro-Thr
Mutant 1: Met-Trp
Mutant 2: Met-Trp-His-Arg-Gly-Ser-Pro-Thr
Mutant 3: Met-Cys-Ile-Val-Val-Val-Gln-His _

Use this information to answer the following questions:

Another mutation (mutant 4) is isolated. Its amino acid sequence is unchanged from wild type, but the mutant cells produce abnormally low amounts of the wild-type proteins. As specifically as you can, predict where this mutation exists in the gene.

Accepted Answer

Hi everyone. Let's take a look at this practice problem together. Which of the following is considered the least harmful type of mutation? Let's just go ahead and go through the mutations and talk about them. We have a miss sensed mutation. Now this is a substitution mutation and it's where a single base pair is substituted. This changes the code on so that it encodes a completely different amino acid from the original. In be an insertion mutation. This adds a single nucleotide to the sequence and it can shift the whole reading frame. So the whole code on reading frame. Now. What this effects is that all code ons that are downstream from the mutation can result in a completely different amino acid sequence than what was originally encoded. Then we have. See a deletion mutation and this is where a single nucleotide is deleted and the same occurs as an insertion mutation. You get the shifting of the code on reading frame and that affects the whole amino acid sequence downstream from the mutation. Our last option D. Silent mutation. Now this is another substitution mutation and it's wear the new coat on. Still encodes the same amino acid so you produce the same amino acid. This is the least harmful out of all the options because it does not affect the amino acid sequence. So D is the correct correct answer. Alright everyone. I hope you found this helpful and I'll see you soon for the next practice problem

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