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Ch. 33 - Viruses
Chapter 32, Problem 10

Which of the following types of viruses would you expect to require periods of latency? a. viruses that have large genomes and require a long time for replication b viruses that require a long time for transmission to new hosts c viruses that require a long time for assembly into complex structures d. viruses that infect cells of the immune system

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Latency in Viruses

Latency refers to a period during which a virus remains dormant within a host cell without producing new viral particles. This state can be crucial for the virus's survival, allowing it to evade the host's immune response and re-emerge later to cause infection. Understanding latency is essential for recognizing how certain viruses can persist in the body and reactivate under specific conditions.
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Immune System Targeting

Viruses that infect immune system cells, such as HIV, can manipulate the host's immune response, leading to periods of latency. By targeting immune cells, these viruses can hide from immune detection and persist in the body, complicating treatment and increasing the risk of reactivation. This concept is vital for understanding the dynamics of viral infections and their long-term implications.
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Viral Replication and Assembly

Viral replication involves the processes by which a virus makes copies of itself within a host cell, while assembly refers to the formation of new viral particles. Some viruses may require longer times for these processes, but this does not inherently lead to latency. Instead, latency is more closely associated with the virus's ability to remain undetected by the immune system, particularly in the case of those targeting immune cells.
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Related Practice
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If you come down with the flu, should your physician prescribe an antibiotic for you? Explain why or why not.

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Textbook Question

Of the viruses highlighted in Section 33.4, predict which of the following would be able to make viral proteins if nothing more than its genome were injected into a suitable host cell. a. pea mosaic ([+]ssRNA) virus b. bluetongue (dsRNA) virus c. measles ([−]ssRNA) virus d. human immunodeficiency (RNA reverse-transcribing) virus

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Textbook Question

If you were in charge of the government's budget devoted to stemming the AIDS epidemic, would you devote most of the resources to drug development or preventive medicine? Defend your answer.

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Textbook Question

The mosquito-borne Zika virus (ZIKV) is one of the most feared viruses for pregnant women. Recent statistics justify this fear: Infants born to mothers infected with ZIKV during pregnancy face a risk of up to 42 percent of developing birth defects, including microcephaly (an abnormally small head and decreased brain volume). What do we know about how ZIKV causes damage to the developing brain? ZIKV is a Baltimore class IV virus. Based on this classification, what do you know about the structure of its genome?

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Textbook Question

The mosquito-borne Zika virus (ZIKV) is one of the most feared viruses for pregnant women. Recent statistics justify this fear: Infants born to mothers infected with ZIKV during pregnancy face a risk of up to 42 percent of developing birth defects, including microcephaly (an abnormally small head and decreased brain volume). What do we know about how ZIKV causes damage to the developing brain? Researchers have determined that host cells possess several different surface proteins that can serve as virus receptors for ZIKV. If you were to repeat the experiment described in Figure 33.8 using ZIKV instead of HIV, how would you expect the results to be different? Explain.

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Textbook Question

The mosquito-borne Zika virus (ZIKV) is one of the most feared viruses for pregnant women. Recent statistics justify this fear: Infants born to mothers infected with ZIKV during pregnancy face a risk of up to 42 percent of developing birth defects, including microcephaly (an abnormally small head and decreased brain volume). What do we know about how ZIKV causes damage to the developing brain? Several lines of evidence suggest that after ZIKV is transmitted to a pregnant woman via the bite of an infected mosquito, the virus then directly infects cells of the placenta, gaining access to the fetal brain. Following attachment, the virion would most likely enter the placental cell by: a. insertion via the mosquito's mouthparts b. endocytosis c. degrading the cell wall with lysozyme d. injection through a hollow, needle-like protein structure

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