Skin color is often one of the first traits people notice in each other. Studies in zebrafish uncovered a mutation that altered a transport protein and resulted in light-colored fish. This discovery led to the finding that the same gene in humans has a strong influence on skin pigmentation in many populations. The zebrafish mutation that reduced coloration created a null allele of the transport protein gene. Which of the following types of mutation would be most likely to create this null allele? a. a missense mutation b. a frameshift mutation c. a neutral mutation d. a silent mutation

Video transcript

Hello everyone. And in today's video we have the following problem. Sickle cell anemia is an inherited disorder. It affects the shape of red blood cells which carry oxygen to all parts of the body due to a single shape it becomes more rigid, slowing and blocking the blood flow. The disorder is caused by a single nucleotide difference in the hemoglobin gene which causes glycemic acid which is a negative amino acid to turn into value which is a hydrophobic amino acid. This type of mutation is an example of blank. So here we need to identify which type of mutation we have in hand. Now since we have a single nucleotide difference, I want you to just realize that we're dealing with point mutations because only one nucleotide was exchanged by another. So let's look at the type of point mutations that we have available. So we can identify the correct one. Beginning by these mutations called nonsense mutations and in this case they create a stop code on we have that the mutation resulted in atomic asset to turn into value. So this is an incorrect answer choice and we will cancel it out. Then we have silent mutations which involve a change of amino acid for the same amino acid or an equivalent one which has no effect on the protein. So this is going to be assigned a mutation and it is not what is being described here because this glue atomic acid is a negative amino acid while Violin is hydrophobic. Now this guy tannic acid because it is negative, it's going to be hydra filic. So they're not equivalent. They're very different assets. So this is also not going to be the correct answer choice and we will cancel it out. Then we have insertions. Now insertions are a type of frame shift mutation, they're not going to be point mutations. So we will cancel this out as well. Finally we have mis sense mutations. If we read here we have that we create a different amino acid which usually have negative effects. Here we have the tannic acid turning into value which is a different amino acid and as we can see here they have many different properties that are not equivalent. They're very different. So this is going to be the correct answer choice miss sense mutation and we will highlight answer choice C as the final answer to our question. I really hope this video helped you and I hope to see you on the next one.