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Ch. 42 - Circulation and Gas Exchange
Chapter 42, Problem 7

Compared with the interstitial fluid that bathes active muscle cells, blood reaching these cells in arterioles has a a. higher PO2. b. higher PCO2. c. greater bicarbonate concentration. d. lower pH.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Partial Pressure of Gases

Partial pressure refers to the pressure exerted by a single type of gas in a mixture of gases. In the context of oxygen (O2) and carbon dioxide (CO2), the partial pressures in blood and interstitial fluid influence gas exchange. Active muscle cells consume oxygen and produce carbon dioxide, leading to differences in partial pressures that drive diffusion across membranes.
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Bicarbonate Buffer System

The bicarbonate buffer system is a crucial physiological mechanism that helps maintain pH balance in the blood and interstitial fluid. It involves the equilibrium between carbonic acid (H2CO3), bicarbonate ions (HCO3-), and carbon dioxide (CO2). Changes in bicarbonate concentration can affect pH levels, which is important for muscle function and metabolic processes.
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Acid-Base Balance

Acid-base balance refers to the regulation of pH levels in the body fluids, which is vital for normal cellular function. Active muscle metabolism produces acids, leading to a decrease in pH (acidosis) in the interstitial fluid. Understanding how blood and interstitial fluid differ in pH and gas concentrations is essential for comprehending muscle physiology and metabolic responses.
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