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Ch. 12 - The Cell Cycle
Chapter 12, Problem 5

Which of the following occurs during apoptosis? (A) lysis of the cell (B) direct contact between signaling cells (C) fragmentation of the DNA (D) release of proteases outside the cell

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1
Understand the term 'apoptosis', which is a process of programmed cell death that occurs in multicellular organisms. This process is crucial for maintaining the health of an organism by eliminating old, unnecessary, or unhealthy cells.
Identify what typically happens during apoptosis: the cell shrinks and condenses, the DNA and cytoplasmic contents are fragmented, and the cell's parts are packaged into small vesicles called apoptotic bodies.
Analyze option (A) lysis of the cell: Lysis refers to the breaking down of the cell membrane, causing the cell to burst. This is more characteristic of necrosis, not apoptosis.
Analyze option (B) direct contact between signaling cells: This option describes a form of cell communication which is not specific to the process of apoptosis.
Analyze option (C) fragmentation of the DNA: During apoptosis, the cell's DNA is fragmented by specific enzymes as part of the controlled process of cell death.
Analyze option (D) release of proteases outside the cell: In apoptosis, proteases called caspases are activated within the cell to degrade cell components, not released outside.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Apoptosis

Apoptosis is a programmed cell death process that is essential for maintaining cellular homeostasis and development. Unlike necrosis, which results in cell lysis and inflammation, apoptosis is a controlled mechanism that leads to the orderly dismantling of cellular components without causing harm to surrounding tissues.
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DNA Fragmentation

During apoptosis, one of the hallmark features is the fragmentation of DNA. This process is mediated by specific enzymes called caspases, which activate nucleases that cleave the DNA into smaller pieces, ultimately leading to the cell's demise. This fragmentation is a key indicator of apoptosis and helps in the removal of the dying cell by phagocytes.
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Caspases

Caspases are a family of cysteine proteases that play a crucial role in the execution of apoptosis. They are synthesized as inactive precursors and are activated in response to pro-apoptotic signals. Once activated, caspases orchestrate the apoptotic process by cleaving various cellular substrates, leading to the characteristic morphological changes associated with apoptosis.