Unlike prokaryotic DNA replication, replication of eukaryotic chromosomes __________.

• A. involves two leading strands and no lagging strands
• B. is semiconservative
• C. has a single origin
• D. is error-free
• E. cannot be completed by DNA polymerase

Answer: (E)

Verified step by step guidance

1. Understand that eukaryotic chromosomes are linear, unlike the circular chromosomes of prokaryotes. This structural difference impacts how replication is completed.
2. Recognize that DNA polymerase can only add nucleotides to the 3' end of a DNA strand, which creates a problem at the ends of linear chromosomes, known as telomeres.
3. Learn that the inability of DNA polymerase to fully replicate the 3' ends of linear DNA strands results in the gradual shortening of telomeres with each cell division.
4. Identify that eukaryotic cells use an enzyme called telomerase to extend the telomeres, compensating for the incomplete replication by DNA polymerase.
5. Conclude that the statement 'cannot be completed by DNA polymerase' refers to the inability of DNA polymerase to finish replicating the very ends of linear chromosomes, necessitating the role of telomerase.