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Ch. 21 The Immune System: Innate and Adaptive Body Defenses
Chapter 20, Problem 8

Which of the following is not involved in the activation of a B cell? a. antigen, b. helper T cell, c. cytokine, d. cytotoxic T cell.

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1
Identify the role of each option in the immune response.
Understand that B cells are a type of white blood cell involved in the humoral immune response.
Recognize that antigens are substances that trigger an immune response, leading to B cell activation.
Know that helper T cells assist in the activation of B cells by releasing cytokines.
Realize that cytotoxic T cells are primarily involved in killing infected cells, not in the activation of B cells.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

B Cell Activation

B cell activation is a crucial process in the adaptive immune response, where B cells recognize specific antigens. This activation typically requires the binding of an antigen to the B cell receptor (BCR) and often involves additional signals from helper T cells, which enhance the B cell's response and promote its differentiation into plasma cells that produce antibodies.
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B Cell Receptors

Role of Helper T Cells

Helper T cells play a vital role in the immune system by providing necessary signals for B cell activation. Upon recognizing an antigen presented by antigen-presenting cells, helper T cells release cytokines that stimulate B cells, facilitating their proliferation and differentiation into antibody-secreting cells, thus enhancing the immune response.
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Review of Cytotoxic vs Helper T Cells

Cytotoxic T Cells

Cytotoxic T cells are a type of T cell that primarily function to kill infected or cancerous cells. Unlike helper T cells, they do not directly participate in B cell activation. Their main role is to recognize and destroy cells presenting foreign antigens, making them less relevant in the context of B cell activation compared to helper T cells and cytokines.
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Review of Cytotoxic vs Helper T Cells