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Ch. 21 The Immune System: Innate and Adaptive Body Defenses
Chapter 20, Problem 13

Besides acting as mechanical barriers, the skin epidermis and mucosae of the body have other attributes that contribute to their protective roles. Cite the common body locations and the importance of mucus, lysozyme, keratin, acid pH, and cilia.

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Identify the common body locations where the skin epidermis and mucosae are found, such as the outer layer of the skin, respiratory tract, digestive tract, and urogenital tract.
Explain the role of mucus in these locations, highlighting its function in trapping pathogens and particles, and its presence in areas like the respiratory and digestive tracts.
Discuss the importance of lysozyme, an enzyme found in secretions like saliva and tears, which helps break down bacterial cell walls, providing an antimicrobial defense.
Describe the role of keratin, a protein found in the skin, hair, and nails, which provides a tough, protective barrier against physical damage and pathogens.
Explain how acid pH, found in areas like the stomach and skin, creates an inhospitable environment for many pathogens, and how cilia, tiny hair-like structures in the respiratory tract, help move mucus and trapped particles out of the body.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Mucus

Mucus is a viscous secretion produced by mucous membranes that serves as a protective barrier in various body locations, such as the respiratory and gastrointestinal tracts. It traps pathogens, dust, and other particles, preventing them from entering the body. Additionally, mucus contains antimicrobial properties that help neutralize harmful microorganisms.
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Lysozyme

Lysozyme is an enzyme found in various body fluids, including saliva and tears, that breaks down the cell walls of certain bacteria, providing an important defense mechanism. It is particularly effective against Gram-positive bacteria, contributing to the body's innate immune response. Its presence in secretions helps to maintain a sterile environment in areas like the eyes and respiratory tract.
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Keratin and Acid pH

Keratin is a fibrous protein found in the skin's epidermis that provides structural strength and waterproofing, making the skin a formidable barrier against environmental threats. Acid pH, particularly in the skin and stomach, inhibits the growth of harmful bacteria and pathogens, creating an unfavorable environment for their survival. Together, these factors enhance the skin's protective role against infections.
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