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Ch. 21 The Respiratory System
Chapter 21, Problem 21.2a

What happens to the metabolic rate of skeletal muscle tissue during exercise? What waste products are produced from metabolic reactions? How and why does this affect your rate of ventilation during exercise?

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During exercise, the metabolic rate of skeletal muscle tissue increases significantly to meet the higher energy demands.
The primary waste products produced from increased metabolic reactions in skeletal muscles are carbon dioxide (CO_2) and lactic acid.
As the metabolic rate increases, more CO_2 is produced as a byproduct of aerobic respiration, and lactic acid may accumulate if anaerobic respiration occurs.
The increase in CO_2 levels in the blood leads to a decrease in blood pH, which is detected by chemoreceptors in the body.
In response to the increased CO_2 and decreased pH, the rate of ventilation (breathing) increases to expel more CO_2 and maintain acid-base balance.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Metabolic Rate

Metabolic rate refers to the rate at which the body converts food into energy. During exercise, the metabolic rate of skeletal muscle tissue increases significantly to meet the heightened energy demands. This increase is primarily due to enhanced ATP production through aerobic and anaerobic pathways, allowing muscles to sustain prolonged activity.
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Waste Products of Metabolism

During metabolic reactions, particularly in skeletal muscle during exercise, waste products such as carbon dioxide (CO2) and lactic acid are produced. CO2 is generated from aerobic respiration, while lactic acid is a byproduct of anaerobic metabolism when oxygen levels are insufficient. The accumulation of these waste products can influence muscle fatigue and overall performance.
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Ventilation Rate

Ventilation rate refers to the amount of air inhaled and exhaled from the lungs per minute. During exercise, the production of CO2 increases, leading to a rise in acidity in the blood, which stimulates the respiratory center in the brain. This results in an increased ventilation rate to expel excess CO2 and maintain acid-base balance, ensuring that oxygen supply meets the demands of active muscles.
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Related Practice
Textbook Question

Henry's law states that the degree to which a gas dissolves in a liquid is determined by its:


a. partial pressure.

b. solubility.

c. surface tension.

d. Both a and b are correct.

e. All of the above are correct.

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Textbook Question

Fill in the blanks: When the alveolar Po₂ decreases, the pulmonary arterioles_____. When the arteriolar Pco₂ increases, the bronchioles_______.

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Textbook Question

If you swallow a large bite of food without properly chewing it first, you will feel discomfort during ventilation. Explain this, considering the arrangement of the trachea and the esophagus.

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Textbook Question

You and a friend are having a contest to see who can hold his or her breath the longest. Your friend hyperventilates before holding his breath, and subsequently wins the contest. Why did hyperventilation give him an advantage?

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Textbook Question

Predict what would happen to the tidal volume and inspiratory reserve volume if the phrenic nerves were severed. Which muscles would contract to try to compensate for this?

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Textbook Question

Which of the following statements about pulmonary ventilation is false?


a. Normal expiration requires the use of the expiratory muscles to decrease lung volume.

b. The inspiratory muscles increase lung volume, which decreases intrapulmonary pressure.

c. For inspiration to occur, intrapulmonary pressure must decrease below atmospheric pressure.

d. The intrapleural pressure is less than the intrapulmonary pressure; this prevents the lungs from collapsing during expiration.

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