The following are statements regarding the role of different substances in the process of blood clotting. 

P. Prothrombin is a key protein involved in the coagulation cascade.

Q. Sodium acts as a cofactor for various enzymes involved in coagulation 

R. Fibrinogen is a soluble protein found in the blood that is converted into fibrin during blood clotting 

S. Vitamin K is essential for the synthesis of several blood clotting factors in the liver.

Which of the following options includes all the correct statements?