Which type of pattern recognition receptor when bound to MAMPs triggers the formation of the inflammasome?

• A. NOD-Like Receptors.
• B. RIG-Like Receptors.
• C. Toll-Like Receptors.
• D. C-Type Lectin Receptors.

Answer: (A)

Verified step by step guidance

1. Understand the role of pattern recognition receptors (PRRs) in the immune system. PRRs are proteins capable of recognizing molecules frequently found in pathogens, known as microbe-associated molecular patterns (MAMPs).
2. Identify the different types of PRRs mentioned: NOD-Like Receptors, RIG-Like Receptors, Toll-Like Receptors, and C-Type Lectin Receptors. Each of these receptors has a specific function and location within the cell.
3. Focus on the function of NOD-Like Receptors (NLRs). These are intracellular receptors that detect MAMPs and other danger signals within the cytoplasm of the cell.
4. Learn about the inflammasome, a multiprotein complex that is formed in response to the activation of certain NLRs. The inflammasome plays a crucial role in the activation of inflammatory responses.
5. Conclude that when NOD-Like Receptors bind to MAMPs, they trigger the formation of the inflammasome, leading to the activation of inflammatory pathways.