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Genetic Analysis: An Integrated Approach, 3rd edition

Published by Pearson (January 9, 2018) © 2019

  • Mark F. Sanders
  • John L. Bowman Monash University

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For all introductory genetics courses.

Real world applications of genetics

Genetic Analysis: An Integrated Approach shares excitement about genetics and the dynamism at work in the field. This integrated approach helps contextualize 3 core challenges of learning genetics: solving problems, understanding the connection between traditional genetics models and more modern approaches, and understanding evolution.

The 3rd Edition provides additional problem-solving guidance and an emphasis on real-world applications of genetics. The revision offers ways to facilitate group work and keeps pace with changes in the field including CRISPR-Cas, epigenetics and expanded coverage of genomic approaches.

Hallmark features of this title

Problem-solving skills

  • Genetic Analysis worked examples guide students using a consistent 3-step approach of Evaluate, Deduce, and then Solve problems.
  • Break It Down prompts in worked examples start students in formulating an approach to solving a problem by breaking down essential information.

Applications of genetics

  • Case Studies are real-world examples that highlight chapter concepts and show practical applications of genetics.
  • 9 Foundation Figures combine visuals and words to help students grasp pivotal genetics concepts in a concise, easy-to-follow format.
  • An integrated evolutionary perspective helps students keep sight of important evolutionary principles while learning core concepts.

New and updated features of this title

Problem-solving skills

  • Preparing for Problem Solving draws students' attention back to the major ideas in the chapter and to the practical skills modeled before they work the end-of-chapter problems.
  • Collaboration and Discussion problems in end-of-chapter problem sets offer opportunities for comprehensive, hands-on problem solving in small groups working together.
  • The accompanying Student Solutions Manual and Study Guide provides additional worked problems and solutions to problems in the text.
  • End-of-Chapter Problems are divided into separate sections labeled Chapter Concepts and Application and Integration. Even-numbered problems answers appear in the Appendix.

Applications of genetics

  • 5 Application Chapters explore highly relevant, engaging topics in human genetics to illustrate some of the practical uses of genetics and genetic analysis.
  • Several chapters reflect new approaches to genetic analysis. Ch 5: discussion of mapping of molecular genetic markers; Ch 13: discussion of epigenetic regulation and roles of epigenetic readers, writers, and erasers; Ch 14 & Ch 15: coverage of the CRISPR–Cas9 system and gene editing applications; Ch 16 & Ch 18: genomic approaches.

Highlights of the DIGITAL UPDATE for Mastering Genetics (available for Fall 2021 classes)

Instructors, contact your sales rep to ensure you have the most recent version of the course.

  • NEW: Visualizing Genetics videos walk students through identifying what's shown in a figure and how to apply the information for use in the future. The feature has 4 discrete elements: Evaluate, Assess, Interpret, and Connect,
  • NEW: Practice Problems provide tutorials that build in complexity and cover gaps in content. 140 Practice Problems can be assigned for homework or practice. Targeted, wrong-answer feedback helps students learn from their mistakes.
  • NEW: Break It Down practice problems are included as 2 end-of-chapter problems to start students in formulating an approach to solving a problem.

Features of Mastering Genetics for the 3rd Edition; published 2018

  • Over 120 activities and tutorials focus on key genetics concepts, reinforcing problem-solving skills with hints and feedback specific to misconceptions and errors.
  • Approximately 90% of the end-of-chapter problems can be assigned as auto-graded homework and prepare students for challenging problems they are likely to see on exams.
  • Publisher Pre-built Assignments, curated by experienced Mastering Genetics users, consist of content focused on the key ideas of each chapter.

Features of Pearson eText for the 3rd Edition; published 2021

  • NEW: Content updates include cancer, genomics, epigenetics, nonsense mediated decay, and 3rd generation sequencing to reflect changing areas of research in relevant sections.
  1. The Molecular Basis of Heredity, Variation, and Evolution
  2. Transmission Genetics
  3. Cell Division and Chromosome Heredity
  4. Gene Interaction
  5. Genetic Linkage and Mapping in Eukaryotes
  6. Genetic Analysis and Mapping in Bacteria and Bacteriophage

APPLICATION A: HUMAN HEREDITARY DISEASE AND GENETIC COUNSELING

  1. DNA Structure and Replication
  2. Molecular Biology of Transcription and RNA Processing
  3. The Molecular Biology of Translation

APPLICATION B: HUMAN GENETIC SCREENING

  1. Eukaryotic Chromosome Abnormalities and Molecular Organization
  2. Gene Mutation, DNA Repair, and Homologous Recombination
  3. Regulation of Gene Expression in Bacteria and Bacteriophage
  4. Regulation of Gene Expression in Eukaryotes
  5. Analysis of Gene Function by Forward Genetics and Reverse Genetics

APPLICATION C: THE GENETICS OF CANCER

  1. Recombinant DNA Technology and Its Applications
  2. Genomics: Genetics from a Whole-Genome Perspective
  3. Organellar Inheritance and the Evolution of Organellar Genomes
  4. Developmental Genetics
  5. Genetic Analysis of Quantitative Traits
  6. Population Genetics and Evolution at the Population, Species, and Molecular Levels

APPLICATION D: HUMAN EVOLUTIONARY GENETICS

APPLICATION E FORENSIC GENETICS

About our authors

Mark F. Sanders has been a faculty member in the Department of Molecular and Cellular Biology at the University of California, Davis, since 1985. In that time, he has taught more than 150 genetics courses to nearly 35,000 undergraduate students. Although he specializes in teaching the genetics course for which this book is written, his genetics teaching experience also includes a genetics laboratory course, an advanced human genetics course for biology majors, and a human heredity course for nonscience majors, as well as introductory biology and courses in population genetics and evolution. He has also served as an advisor to undergraduate students and in undergraduate education administration, and he has directed several undergraduate education programs.

Dr. Sanders received his B.A. degree in Anthropology from San Francisco State University, his M.A. and Ph.D. degrees in Biological Anthropology from the University of California, Los Angeles, and 4 years of training as a postdoctoral researcher studying inherited susceptibility to human breast and ovarian cancer at the University of California, Berkeley.

John L. Bowman is a professor in the School of Biological Sciences at Monash University in Melbourne, Australia, and an adjunct professor in the Department of Plant Biology at the University of California, Davis, in the United States. He received a B.S. in Biochemistry at the University of Illinois at Urbana-Champaign in 1986 and a Ph.D. in Biology from the California Institute of Technology in Pasadena, California. His Ph.D. research focused on how the identities of floral organs are specified in Arabidopsis (described in Chapter 18), and he conducted postdoctoral research at Monash University on the regulation of floral development. From 1996 to 2006, his laboratory at UC Davis investigated developmental genetics of plants, focusing on how leaves are patterned. From 2006 to 2011, he was a Federation Fellow at Monash University, where his laboratory is studying land plant evolution using a developmental genetics approach. He was elected a Fellow of the Australian Academy of Science in 2014. At UC Davis he taught genetics, from Mendel to cancer, to undergraduate students, and he continues to teach genetics courses at Monash University.

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