Biochemistry: Concepts and Connections, 2nd edition
Published by Pearson (January 11, 2018) © 2019
- Dean R Appling The University of Texas at Austin
- Spencer J. Anthony-Cahill Western Washington University
- Christopher K. Mathews Oregon State University
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Mastering
- Activate learning for future scientists
- Tailor your course to fit your needs
- Support students with guided practice
For courses in biochemistry.
Engage students visually and through real-world applications
Biochemistry: Concepts and Connections engages students with a unique approach to visualization, synthesis of complex topics and connections to the real world. The authors build quantitative reasoning skills and provide a chemical perspective on biological processes. The text also shows how biochemistry relates to practical real-world applications.
The 2nd Edition provides new Threshold Concept Tutorials to help students master challenging and critical ideas in biochemistry. Revised Concept and Connection statements call students' attention to fundamental concepts as well as real-world applications.
Hallmark features of this title
- The groundbreaking visual narrative highlights and reinforces overarching themes such as chemical logic, regulation, interface between chemistry, and biology. Graphic presentations include macromolecules to cellular structures as well as reaction mechanisms and metabolic pathways.Â
- All is art created by medical illustrators and reviewed by a faculty advisory board made up of members of VIBE (Visualization in Biochemistry Education) Research Group to ensure that all visuals are accurate and pedagogically sound.
- Complex multi-step art pieces are tied to in-text discussions with color-coded step callouts that allow students to more easily connect the details in the text to the art.
New and updated features of this title
- EXPANDED: Foundation Figures visually integrate core chemical and biological connections, providing a way for students to organize highly complex and detailed material while making biochemistry more manageable, understandable, and easier to synthesize.Â
- EXPANDED: Tools of Biochemistry highlight the most important research techniques and emphasize biochemistry as an experimental science with cutting edge references such as links to Nobel Prize lectures.
- REVISED: Concept and Connection statements highlighted in the narrative call students' attention to fundamental concepts as well as real-world applications to demonstrate how individual topics are related.
- NEW: End-of-chapter problems include real-world applications. Approximately half of the problems include brief answers at the end of the book.
Features of Mastering Chemistry for the 2nd Edition
- EXPANDED: Foundations Figure Tutorials walk students through 2-page text spreads, using stepwise animations to break them into tractable pieces. Follow-up questions assess student understanding.
- Threshold Concept Tutorials help students assess their understanding and master important threshold concepts that often act as barriers to learning the content in biochemistry courses.
- Interactive Case Studies put students into the role of a biochemist in real-world scenarios, immersing them in timely topics. Problems connect the course material to the real world by exploring actual scientific data from primary literature.
- UPDATED: Biochemistry-Specific Tutorial Problems cover biochemistry topics and new real-world applications such as non-glucose metabolism. Problems include wrong-answer feedback with hints.
- EXPANDED: 100 New End-of-Chapter Problems are assignable in Mastering and help students prepare for the types of questions that may appear on an exam. All include author-written solutions.
- Biochemistry and the Language of Chemistry
- The Chemical Foundation of Life: Weak Interactions in an Aqueous Environment
- The Energetics of Life
- Nucleic Acids
- Introduction to Proteins: The Primary Level of Protein Structure
- The Three-Dimensional Structure of Proteins
- Protein Function and Evolution
- Enzymes: Biological Catalysts
- Carbohydrates: Sugars, Saccharides, Glycans
- Lipids, Membranes, and Cellular Transport
- Chemical Logic of Metabolism
- Carbohydrate Metabolism: Glycolysis, Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway
- The Citric Acid Cycle
- Electron Transport, Oxidative Phosphorylation, and Oxygen Metabolism
- Photosynthesis
- Lipid Metabolism
- Interorgan and Intracellular Coordination of Energy Metabolism in Vertebrates
- Amino Acid and Nitrogen Metabolism
- Nucleotide Metabolism
- Mechanisms of Signal Transduction
- Genes, Genomes, and Chromosomes
- DNA Replication
- DNA Repair, Recombination, and Rearrangement
- Transcription and Post-transcriptional Processing
- Information Decoding: Translation and Post-translational Protein Processing
- Regulation of Gene Expression
APPENDICES
- Answers to Selected Problems
- References
Glossary
Credits
Index
About our authors
Dean R. Appling is the Lester J. Reed Professor of Biochemistry and the Associate Dean for Research and Facilities for the College of Natural Sciences at the University of Texas at Austin, where he has taught and done research for the past 29 years. Dean earned his B.S. in Biology from Texas A&M University (1977) and his Ph.D. in Biochemistry from Vanderbilt University (1981). The Appling laboratory studies the organization and regulation of metabolic pathways in eukaryotes, focusing on folate-mediated one-carbon metabolism. The lab is particularly interested in understanding how one-carbon metabolism is organized in mitochondria, as these organelles are central players in many human diseases. In addition to coauthoring Biochemistry, Fourth Edition, a textbook for majors and graduate students, Dean has published over 60 scientific papers and book chapters.
As much fun as writing a textbook might be, Dean would rather be outdoors. He is an avid fisherman and hiker. Recently, Dean and his wife, Maureen, have become entranced by the birds on the Texas coast. They were introduced to bird-watching by coauthor Chris Mathews and his wife Kate–an unintended consequence of writing textbooks!
Spencer J. Anthony-Cahill is a Professor in the Department of Chemistry at Western Washington University (WWU)in Bellingham, WA. Spencer earned his B.A. in chemistry from Whitman College, and his Ph.D. in bioorganic chemistry from the University of California, Berkeley. His graduate work, in the laboratory of Peter Schultz, focused on the biosynthetic incorporation of unnatural amino acids into proteins. Spencer was an NIH postdoctoral fellow in the laboratory of Bill DeGrado (then at DuPont Central Research), where he worked on de novo peptide design and the prediction of the tertiary structure of the HLH DNA-binding motif. He then worked for five years as a research scientist in the biotechnology industry, developing recombinant hemoglobin as a treatment for acute blood loss. In 1997, Spencer decided to pursue his long-standing interest in teaching and moved to WWU, where he is today. In 2012, Spencer was recognized by WWU with the Peter J. Elich Award for Excellence in Teaching.
Research in the Anthony-Cahill laboratory is directed at the protein engineering and structural biology of oxygen-binding proteins. The primary focus is on circular permutation of human â-globin as a means of developing a single-chain hemoglobin with desirable therapeutic properties as a blood replacement.
Outside the classroom and laboratory, Spencer is a great fan of the outdoors–especially the North Cascades and southeastern Utah, where he has often backpacked, camped, climbed, and mountain biked. He also plays electric bass (poorly) in a local blues-rock band and teaches Aikido in Bellingham.
Christopher K. Mathews is Distinguished Professor Emeritus of Biochemistry at Oregon State University. He earned his B.A. in chemistry from Reed College (1958) and Ph.D. in biochemistry from the University of Washington (1962). He served on the faculties of Yale University and the University of Arizona from 1963 until 1978. When he moved to Oregon State University he became Chair of the Department of Biochemistry and Biophysics, a position he held until 2002. His major research interest is the enzymology and regulation of DNA precursor metabolism and the intracellular coordination between deoxyribonucleotide synthesis and DNA replication. From 1984 to 1985, Dr. Mathews was an Eleanor Roosevelt International Cancer Fellow at the Karolinska Institute in Stockholm, and in 1994-1995 he held the Tage Erlander Guest Professorship at Stockholm University. Dr. Mathews has published about 185 research papers, book chapters, and reviews dealing with molecular virology, metabolic regulation, nucleotide enzymology, and biochemical genetics. From 1964 until 2012 he was a principal investigator on grants from the National Institutes of Health, National Science Foundation, and the Army Research Office. He is the author of Bacteriophage Biochemistry (1971) and coeditor of Bacteriophage T4 (1983) and Structural and Organizational Aspects of Metabolic Regulation (1990). He was lead author of four editions of Biochemistry, a textbook for majors and graduate students. His teaching experience includes undergraduate, graduate, and medical school biochemistry courses.
He has backpacked the mountains and floated the rivers, respectively, of Oregon and the Northwest. As an enthusiastic birder he has served as President of the Audubon Society of Corvallis and is President of the Great Basin Society, which operates the Malheur Field Station in eastern Oregon.
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