Now we're going to get some practice proposing aromatic synthesis, specifically using diazoreplacement reactions. As you guys know, a big part of this topic is being able to turn a smaller benzene into a bigger one. We must use our knowledge of sequence groups and blocking groups to plan out our synthesis in the correct order. You should have already had some practice with this at this point, so I'm going to leave these up to you completely. Go ahead and try to do this one from scratch with everything you know about diazo, and then I'll step in and show you guys the answer. Go for it.
Diazo Retrosynthesis - Online Tutor, Practice Problems & Exam Prep
Ready for some practice on Aromatic synthesis? You probably have done problems similar to this before but now we want to work specifically using diazo replacement reactions.
Proposing Aromatic Synthesis
Video transcript
Synthesize the target molecule
Synthesize the target molecule
Video transcript
I think this one might have been a little too hard for you considering that you just learned how to use diazole replacement reactions. But I just want to show you an example of a more advanced synthesis that requires pretty much all the different directing effects we've talked about. Before we begin, let's look at a few interesting things here. First of all, notice that I need to add a chlorine in this position here which is tricky because my end product has a meta director here. This is a meta director. I'm probably going to want to add the chlorine before I turn this into a meta director. Right now, this is currently an ortho/para director. I'm probably going to want to add the chlorine before I turn it into a carboxylic acid. Cool. Awesome. What else? Notice that I also have to add an OH here. I have to add an OH here but this chlorine is meta to it. I probably want to have some kind of meta director here before I add that chlorine because once that alcohol is there, it's going t
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