25. Condensation Chemistry

Which of the following reactions lead to the formation of an amide? A. RC=O(OH) + CH3NH2 —> B. RC=O(OCH3) + CH3NH2 Δ—>

What compounds are obtained from the following hydrolysis reactions? c. + H2O HCl Δ—>

Write the mechanism for the acid-catalyzed reaction of tert-butyl acetate with methanol.

Catalytic antibodies catalyze a reaction by forcing the conformation of the substrate in the direction of the transition state. The synthesis of the antibody is carried out in the presence of a transition state analog—a stable molecule that structurally resembles the transition state. This causes an antibody to be generated that recognizes and binds to the transition state, thereby stabilizing it. For example, the following transition state analog has been used to ­generate a catalytic antibody that catalyzes the hydrolysis of the structurally similar ester: Transition state analog H2O—> + a. Draw a possible transition state for the hydrolysis reaction.