Textbook QuestionWhich of the following reactions lead to the formation of an amide? A. RC=O(OH) + CH3NH2 —> B. RC=O(OCH3) + CH3NH2 Δ—>383views
Textbook QuestionWhat compounds are obtained from the following hydrolysis reactions? c. + H2O HCl Δ—>274views
Textbook QuestionWrite the mechanism for the acid-catalyzed reaction of tert-butyl acetate with methanol.385views
Textbook QuestionCatalytic antibodies catalyze a reaction by forcing the conformation of the substrate in the direction of the transition state. The synthesis of the antibody is carried out in the presence of a transition state analog—a stable molecule that structurally resembles the transition state. This causes an antibody to be generated that recognizes and binds to the transition state, thereby stabilizing it. For example, the following transition state analog has been used to generate a catalytic antibody that catalyzes the hydrolysis of the structurally similar ester: Transition state analog H2O—> + a. Draw a possible transition state for the hydrolysis reaction.303views
Textbook QuestionThe following compound has been found to be an inhibitor of penicillinase. The enzyme can be reactivated by hydroxylamine (NH2OH). Propose a mechanism to account for the inhibition.385views
Textbook QuestionThe following compound has been found to be an inhibitor of penicillinase. The enzyme can be reactivated by hydroxylamine (NH2OH). Propose a mechanism to account for the reactivation.354views
Textbook QuestionPropose a mechanism for the rearrangement of the thiazoline obtained from the reaction of Edman's reagent with a peptide to a PTH-amino acid (page 1014). (Hint: Thioesters are very reactive toward nucleophiles.)347views
Textbook QuestionCo2 + catalyzes the hydrolysis of the lactam shown here. Propose a mechanism for the metal-ion catalyzed reaction.347views
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