Textbook QuestionEach of the following heterocycles includes one or more nitrogen atoms. Classify each nitrogen atom as strongly basic or weakly basic, according to the availability of its lone pair of electrons. (d) (e) 652views
Textbook QuestionEach of the following heterocycles includes one or more nitrogen atoms. Classify each nitrogen atom as strongly basic or weakly basic, according to the availability of its lone pair of electrons. (a) (b) (c) 644views
Textbook Questiona. Explain why, when the imidazole ring of histidine is protonated, the double-bonded nitrogen is the nitrogen that accepts the proton. 1005views
Textbook QuestionWhy is the pKa of the arginine side chain greater than the pKa of the lysine side chain?594views
Textbook QuestionHistidine is an important catalytic residue found at the active sites of many enzymes. In many cases, histidine appears to remove protons or to transfer protons from one location to another. (a) Show which nitrogen atom of the histidine heterocycle is basic and which is not. (b) Use resonance forms to show why the protonated form of histidine is a particularly stable cation. (c) Show the structure that results when histidine accepts a proton on the basic nitrogen of the heterocycle and then is deprotonated on the other heterocyclic nitrogen. Explain how histidine might function as a pipeline to transfer protons between sites within an enzyme and its substrate.600views
Textbook QuestionCiprofloxacin is a member of the fluoroquinolone classof antibiotics.(b) Which nitrogen atoms are basic?210views
Textbook QuestionCiprofloxacin is a member of the fluoroquinolone classof antibiotics.(a) Which of its rings are aromatic?215views
Textbook QuestionSome of the following compounds show aromatic properties,and others do not.1. Predict which ones are likely to be aromatic, and explainwhy they are aromatic.2. Predict which nitrogen atoms are more basic than waterand which are less basic.(d) <IMAGE>216views
Textbook QuestionSome of the following compounds show aromatic properties,and others do not.1. Predict which ones are likely to be aromatic, and explainwhy they are aromatic.2. Predict which nitrogen atoms are more basic than waterand which are less basic.(e) <IMAGE>188views
Textbook QuestionSome of the following compounds show aromatic properties, and others do not.1. Predict which ones are likely to be aromatic, and explain why they are aromatic.2. Predict which nitrogen atoms are more basic than water and which are less basic.(f) <IMAGE>203views
Textbook QuestionSome of the following compounds show aromatic properties,and others do not.1. Predict which ones are likely to be aromatic, and explainwhy they are aromatic.2. Predict which nitrogen atoms are more basic than waterand which are less basic.(m) <IMAGE>163views
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