The reaction with 2,5-dimercaptohexane-3,4-diol is intermolecular, making the reaction rate slower, in which k₁ > k_-1, resulting in a lower K_eq; this makes the equilibrium lie more predominantly to the left of the reaction.

The reaction with 2,5-dimercaptohexane-3,4-diol is intramolecular, making the reaction rate faster, in which k₁ > k_-1, resulting in a higher K_eq; this makes the equilibrium lie more predominantly to the left of the reaction.

The reaction with 2,5-dimercaptohexane-3,4-diol is intramolecular, making the reaction rate faster, in which k₁ > k_-1, resulting in a higher K_eq, this makes the equilibrium lie more predominantly to the right of the reaction.

The reaction with 2,5-dimercaptohexane-3,4-diol is intermolecular, making the reaction rate slower, in which k₁ > k_-1, resulting in a lower K_eq, this makes the equilibrium lie more predominantly to the left of the reaction.