in-the-sonogashira-coupling-reaction-tms-acetylene-can-be-utilized-to-link-two-d

Question

In the Sonogashira coupling reaction, TMS-acetylene can be utilized to link two different aryl halides. The trimethylsilyl (TMS) group, commonly used as a protecting group for alcohols, can also serve as a protecting group for terminal alkynes. The deprotection of TMS-acetylene can be achieved by using the KF solution. Demonstrate how TMS-acetylene is used to link 4-iodoaniline and 1-chloro-4-methoxybenzene, as shown below.

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