a-substituted-cyclohexanone-undergoes-base-catalyzed-aldol-cyclization-and-gives-1

Question

A substituted cyclohexanone undergoes base-catalyzed aldol cyclization and gives the following compound. Propose the mechanism of the cyclization to form the product.

Structure of a substituted cyclohexanone for aldol cyclization.

Accepted Answer

Detailed mechanism of intramolecular aldol condensation with reaction arrows.

Answer

Mechanism of intramolecular aldol condensation with reaction steps.

Answer

Alternative mechanism of intramolecular aldol condensation with reaction arrows.

Answer

Another version of the aldol condensation mechanism with reaction arrows.

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A substituted cyclohexanone undergoes base-catalyzed aldol cyclization and gives the following compound. Propose the mechanism of the cyclization to form the product.