an-unknown-drug-has-a-specific-rotation-of-82-the-commercial-synthesis-of-this-d

Question

An unknown drug has a specific rotation of +82°. The commercial synthesis of this drug results in a mixture with an enantiomeric excess of 94%.

i. Determine the absolute configuration (R or S) of this drug.

ii. What is the percentage of each of its enantiomers in the commercial product?

Accepted Answer

i. We can not determine the absolute configuration of this drug with the given data.

ii. (+) enantiomer = 97%, (-) enantiomer = 3%

Answer

i. The absolute configuration of this drug is 'R'.

ii. We can not determine the percentage of each enantiomer using the given data.

Answer

i. The absolute configuration of this drug is 'S'.

ii. (+) enantiomer = 94%, (-) enantiomer = 6%

Answer

i. The absolute configuration of this drug is 'R'.

ii. (+) enantiomer = 97%, (-) enantiomer = 3%