8. Elimination Reactions
E2 - Anti-Coplanar Requirement
1PRACTICE PROBLEM
No E2 reaction is observed when the following stereoisomer of 2-bromo-1,3,4-trimethylcyclohexane is treated with sodium methoxide. Explain this observation.
![](https://lightcat-files.s3.amazonaws.com/problem_images/409746d7a8c92ec9-1673961741519.jpg)
Hint: Examine if there is any hydrogen trans to the leaving group; then see if the two can have a diaxial relationship.
No E2 reaction is observed when the following stereoisomer of 2-bromo-1,3,4-trimethylcyclohexane is treated with sodium methoxide. Explain this observation.
Hint: Examine if there is any hydrogen trans to the leaving group; then see if the two can have a diaxial relationship.