18. Reactions of Aromatics:EAS and Beyond
Electrophilic Aromatic Substitution
18PRACTICE PROBLEM
The reaction of a nitrile with a secondary or tertiary alcohol to produce an N-substituted amide in the presence of an acid is called the Ritter reaction. The reaction includes the nucleophilic addition of a nitrile to a carbenium ion. What is the key difference between the Ritter reaction and the amide formation through acid-catalyzed hydrolysis of a nitrile?
The reaction of a nitrile with a secondary or tertiary alcohol to produce an N-substituted amide in the presence of an acid is called the Ritter reaction. The reaction includes the nucleophilic addition of a nitrile to a carbenium ion. What is the key difference between the Ritter reaction and the amide formation through acid-catalyzed hydrolysis of a nitrile?