7. Substitution Reactions
Substitution Comparison
86PRACTICE PROBLEM
An intramolecular substitution reaction occurs when (1R,2R)-2-chlorocyclohexan-1-ol is treated with a base like NaOH to produce a cyclic ether. However, when (1S,2R)-2-chlorocyclohexan-1-ol is reacted under the same conditions, a diol forms instead. Explain.
![](https://lightcat-files.s3.amazonaws.com/problem_images/ea4e9b7ec871ed1b-1705602376659.jpg)
An intramolecular substitution reaction occurs when (1R,2R)-2-chlorocyclohexan-1-ol is treated with a base like NaOH to produce a cyclic ether. However, when (1S,2R)-2-chlorocyclohexan-1-ol is reacted under the same conditions, a diol forms instead. Explain.