18. Reactions of Aromatics:EAS and Beyond
Electrophilic Aromatic Substitution
6PRACTICE PROBLEM
The electrophilic aromatic substitution reaction rate for indole is 1013 times greater than that of benzene. It often reacts under mild reaction conditions. Substitution in indole occurs preferably at position 3.
![](https://lightcat-files.s3.amazonaws.com/problem_images/704c68d9807f3a4e-1672333397045.jpg)
Explain why indole is more reactive than benzene and why substitution preferably takes place at position 3 than position 2.
The electrophilic aromatic substitution reaction rate for indole is 1013 times greater than that of benzene. It often reacts under mild reaction conditions. Substitution in indole occurs preferably at position 3.
Explain why indole is more reactive than benzene and why substitution preferably takes place at position 3 than position 2.