13. Alcohols and Carbonyl Compounds
Organometallic Cumulative Practice
17PRACTICE PROBLEM
The Reformatsky reaction refers to the addition of an aldehyde or ketone to a carbonyl group using an organozinc reagent. The organozinc reagent exhibits lower reactivity compared to a Grignard reagent, so it does not undergo nucleophilic addition to the ester group. The reagent is prepared by treating an α-bromo ester with zinc.
Provide a synthetic scheme that uses the Reformatsky reaction to synthesize the compound shown below.
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The Reformatsky reaction refers to the addition of an aldehyde or ketone to a carbonyl group using an organozinc reagent. The organozinc reagent exhibits lower reactivity compared to a Grignard reagent, so it does not undergo nucleophilic addition to the ester group. The reagent is prepared by treating an α-bromo ester with zinc.
Provide a synthetic scheme that uses the Reformatsky reaction to synthesize the compound shown below.