22. Condensation Chemistry
Michael Addition
Problem 21.72
Textbook Question
Textbook Question(•••) FROM THE LITERATURE The following reaction was used in the synthesis of aculeatin A, a natural product that is active against KB cell lines. Although it only worked under acidic conditions, a mechanism can be drawn where the reaction might proceed under basic conditions. Suggest this mechanism (J. Org. Chem. 2014, 79, 1498–1504). [The most acidic proton is indicated . . . and number your carbons!]
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