Table of contents

1. A Review of General Chemistry5h 5m
2. Molecular Representations1h 14m
3. Acids and Bases2h 46m
4. Alkanes and Cycloalkanes4h 19m
5. Chirality3h 39m
6. Thermodynamics and Kinetics1h 22m
7. Substitution Reactions1h 48m
8. Elimination Reactions2h 30m
9. Alkenes and Alkynes2h 9m
10. Addition Reactions3h 18m
11. Radical Reactions1h 58m
12. Alcohols, Ethers, Epoxides and Thiols2h 42m
13. Alcohols and Carbonyl Compounds2h 17m
14. Synthetic Techniques1h 26m
15. Analytical Techniques:IR, NMR, Mass Spect7h 3m
16. Conjugated Systems6h 13m
17. Ultraviolet Spectroscopy51m
18. Aromaticity2h 34m
19. Reactions of Aromatics: EAS and Beyond5h 1m
20. Phenols55m
21. Aldehydes and Ketones: Nucleophilic Addition4h 56m
22. Carboxylic Acid Derivatives: NAS2h 51m
23. The Chemistry of Thioesters, Phophate Ester and Phosphate Anhydrides1h 10m
24. Enolate Chemistry: Reactions at the Alpha-Carbon1h 53m
25. Condensation Chemistry2h 9m
26. Amines1h 43m
27. Heterocycles2h 0m
28. Carbohydrates5h 53m
29. Amino Acids3h 20m
30. Peptides and Proteins2h 42m
31. Catalysis in Organic Reactions1h 30m
32. Lipids 2h 50m
33. The Organic Chemistry of Metabolic Pathways2h 52m
34. Nucleic Acids1h 32m
35. Transition Metals6h 14m
36. Synthetic Polymers1h 49m

14. Synthetic Techniques

Alkynide Alkylation

Organic Chemistry

14. Synthetic Techniques

Alkynide Alkylation

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2:30 minutes

Problem 18.29fWade - 9th Edition

Textbook Question

Show how you would accomplish the following syntheses.
You may use whatever additional reagents you need.
(f) <IMAGE of reaction>

Verified step by step guidance

Identify the functional groups present in both the starting material and the target molecule. This will help you determine the type of reactions needed.

Determine the changes that need to occur to transform the starting material into the target molecule. Consider any changes in carbon skeleton, functional groups, or stereochemistry.

Select appropriate reagents and reaction conditions for each transformation step. Consider common organic reactions such as oxidation, reduction, substitution, elimination, or addition reactions.

Plan the synthesis route by organizing the reactions in a logical sequence. Ensure that each step is feasible and that the reagents used are compatible with the functional groups present.

Review the proposed synthesis to ensure that all steps are chemically reasonable and that the overall transformation is efficient. Make any necessary adjustments to optimize the synthesis.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Organic Synthesis

Organic synthesis is the process of constructing organic compounds through chemical reactions. It involves the strategic selection of starting materials and reagents to achieve a desired product. Understanding the principles of synthesis is crucial for designing pathways that efficiently convert reactants into target molecules while considering factors like yield and selectivity.

Reagents and Reaction Conditions

Reagents are substances used in chemical reactions to facilitate the transformation of reactants into products. The choice of reagents and the conditions under which a reaction occurs (such as temperature, pressure, and solvent) can significantly influence the reaction's outcome. Familiarity with common reagents and their roles is essential for successful synthesis.

Mechanism of Reactions

The mechanism of a reaction describes the step-by-step sequence of elementary reactions that lead to the formation of products from reactants. Understanding reaction mechanisms helps chemists predict the behavior of molecules during synthesis, including the formation of intermediates and the transition states. This knowledge is vital for troubleshooting and optimizing synthetic routes.