35. Transition Metals
Sonogashira Coupling Reaction
6:35 minutes
Problem 16.32
Textbook Question
Textbook QuestionThe trimethylsilyl (TMS) group, used as a protecting group for alcohols, can also be used a protecting group for terminal alkynes. Show how TMS-acetylene could be used to link together two aryl halides using the Sonogashira reaction. [Hint: Deprotection of the TMS-acetylene can be done using KF in H₂O .]
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