19. Reactions of Aromatics: EAS and Beyond
Electrophilic Aromatic Substitution
Problem 19d
Textbook Question
Textbook QuestionWe have considered nucleophilic aromatic substitution of pyridine at the 2-position and 3-position but not at the 4-position. Complete the three possible cases by showing the mechanism for the reaction of methoxide ion with 4-chloropyridine. Show how the intermediate is stabilized by delocalization of the charge onto the nitrogen atom.
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