22. Carboxylic Acid Derivatives: NAS
Nucleophilic Acyl Substitution
8:43 minutes
Problem 15l
Textbook Question
Textbook QuestionThe reaction of a nitrile with an alcohol in the presence of a strong acid forms an N-substituted amide. This reaction, known as the Ritter reaction, does not work with primary alcohols. The Ritter reaction RC≡N + R'OH HCl—> RC=O(NHR') a. Propose a mechanism for the Ritter reaction.
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