22. Carboxylic Acid Derivatives: NAS
Acid-Catalyzed Ester Hydrolysis
7:51 minutes
Problem 67c
Textbook Question
Textbook QuestionThe Reformatsky reaction is an addition reaction in which an organozinc reagent is used instead of a Grignard reagent to add to the carbonyl group of
an aldehyde or a ketone. Because the organozinc reagent is less reactive than a Grignard reagent, a nucleophilic addition to the ester group does not occur.
The organozinc reagent is prepared by treating an a-bromo ester with zinc.
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Describe how each of the following compounds can be prepared, using a Reformatsky reaction:
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