13. Alcohols and Carbonyl Compounds
Grignard Reaction
Problem 6b
Textbook Question
Textbook QuestionLOOKING AHEAD We discuss the reaction of Grignard reagents (organomagnesium compounds) to ketones in Chapter 17. Mechanistically, the reaction proceeds by the nucleophilic addition of a methyl carbanion to the electrophilic carbon of the carbonyl, breaking the C―Oπ bond, resulting in an alkoxide intermediate that is subsequently protonated to produce the 3° alcohol. (b) Why, when the substrate is modified slightly, does the reaction result in an excess of one stereoisomer?
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