26. Amines
Amines by Reduction
2:05 minutes
Problem 19.63
Textbook Question
Textbook QuestionReductive amination of aldehydes and ketones is a versatile method for attaching alkyl groups to amines, but the alkyl group is restricted to a 1° or 2° carbon by this method. Prof. Phil Baran of Scripps Research Institute has reported (Science, 2015, 348 (6237), 886–891) a novel way to reduce an aromatic nitro group and add the resulting amine to an alkene so that the aromatic amine is bonded to a 3° carbon—all in a continuous sequence of reactions.
For example:
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Predict the products using these starting materials, all of which are reported in this paper.
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(d) <IMAGE>
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