Here are the essential concepts you must grasp in order to answer the question correctly.
Diapedesis
Diapedesis is the process by which white blood cells, such as macrophages, move out of the bloodstream and into tissues. This occurs when these cells squeeze through the endothelial cells of blood vessels, allowing them to reach sites of infection or injury. Understanding diapedesis is crucial for comprehending how the immune system responds to pathogens.
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Macrophages
Macrophages are a type of white blood cell that play a vital role in the immune system. They are derived from monocytes and are responsible for phagocytosing pathogens, dead cells, and debris. Macrophages can be found in various tissues and are essential for both innate and adaptive immunity, making them key players in the body's defense mechanisms.
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Functions of Helper T Cells (TH):Activation of Macrophages
Wandering vs. Fixed Macrophages
Wandering macrophages, also known as free macrophages, are mobile cells that patrol tissues and can migrate to sites of infection or inflammation. In contrast, fixed macrophages reside in specific tissues and remain stationary. Understanding the difference between these two types of macrophages is important for grasping their roles in immune responses and tissue homeostasis.
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