Intro to Gluconeogenesis - Video Tutorials & Practice Problems
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Intro to Gluconeogenesis Concept 1
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Now, there are two ways that we could get glucose. One way is pretty obvious we eat carbohydrates. A second way to make glucose is to synthesize it and this is where gluco neogenesis comes into play. Now, gluconeogenesis is when your blood glucose is low. And we're gonna say glucose is synthesized from non carbohydrate sources for energy. Now, here we're going to say this is most active when diet is low in carbohydrates or in times of fasting. Now, this is incredibly important that we are able to synthesize glucose during these periods because glucose serves as the major energy source for our brain. Now, here, gluco neogenesis is an anabolic process that occurs mainly in the liver. And recall anabolism involves reactions that use energy to build larger molecules from smaller molecules. If we take a look here at the liver are non-carbohydrate sources. We have as lactate and the amino acids they can be converted to pyruvate, which in turn can be changed into DH A P which remember is dihydroxy acetone phosphate. From there, it can be transformed into the creation of glucose. We can also say that we have Glycerol as yet another way of converting it into DH A P and then towards making glucose. So just remember when it comes to glucose, there's two ways that we can get it, we can eat carbohydrates or we can synthesize them. In this case, synthesis means that we have to utilize gluco neogenesis.
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Intro to Gluconeogenesis Concept 2
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In this video, we'll talk about the difference of gluconeogenesis versus glycolysis. Now, here we're going to say that gluconeogenesis can be viewed as the reverse of glycolysis with some exceptions. So remember with glycolysis, we're starting out with glucose, we go through 10 reactions to get to two pyruvate molecules gluco neogenesis. We're going the other way. We're trying to create pyruvate through non-carbohydrate sources and from pyruvate, we're trying to get back to glucose. Now here, recall when it comes to glycolysis, we say reactions 13 and 10 are irreversible. Now, leon neogenesis bypasses these irreversible reactions by using different enzymes. These enzymes are upregulated whenever your blood glucose levels are low. Ok. So that's how we're able to bypass these irreversible processes that we've seen in glycolysis.
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Intro to Gluconeogenesis Example 1
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Here in this example, question, it says identify all the statements that are not true about gluconeogenesis. So a Leuko Genesis is the exact reverse of the glycolysis pathway. Here. This statement is not true. It is not the exact reverse. There are some exceptions that are allowed or that do happen. OK. So that's why this is not true. It is not an exact opposite or reverse. There are some exceptions, primarily occurs in the liver cells. That is true. Most active in times of fasting or starvation. This is also true. Your blood glucose levels will be low. This is going to kick start the syn synthesis of glucose through gluco genesis. Certain non carbohydrates have to be converted to pyruvate before entering gluconeogenesis pathway. Yes, certain non carbohydrates, we're gonna say lactate amino acids, they have to be converted into pyruvate from pyruvate to DH A P before they can eventually become glucose. So this last statement is true. So out of our four statements only option A is an incorrect or false statement here, Leuko Genesis is not the exact reverse of the glycolysis pathway. It is the reverse with some exceptions that exist
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