In this video, we'll focus on amino acid catabolism in relation to the amino group. Now, here we're going to say the first stage of amino acid catabolism is the removal of the amino group in the liver. Now, this is a two-step process. We're going to say process A is called transamination, process B or process 2 is oxidative deamination. Now, if we take a look here, we see that we have our macromolecules of proteins, carbohydrates, and lipids. You're paying close attention to the digestion of proteins, so we're seeing how that creates our amino acids. Within our cytosol here, we're going to see that our amino acids through transamination, we have the removal of the amino group, and that occurs within the cytosol. Here, if we take a look, our amino acid, we have transamination. We see that we can have the formation of what we call an alpha-keto acid. We'll go into greater details of this; this is just a broad overview of what's going on. We're going to say here, through transamination we also have the generation of what's called Glutamate. This occurs within the mitochondria. And here, we are looking at the mitochondrial matrix in which it occurs. Now, here, once we have our Glutamate, we go into the second part of this process which is oxidative deamination. This is the formation of our Ammonium ion which is NH4+ and again it's occurring within the mitochondria. So through oxidative deamination, we have the formation of the ammonium ion. And then, we also have if we cross the mitochondrial membrane back into the cytosol, we have the alpha-ketoglutarate being produced as well. So here we have stage 1, stage 2 is occurring within the cytosol. We're going to say here that part of this traverses across the mitochondrial membrane into the mitochondrial matrix where we have glutamate, the production of the ammonium ion, and then going back across the mitochondrial membrane, we have our Alpha Ketoglutarate. So just keep in mind, when it comes to amino acid catabolism in relation to the amino group, we have transamination and then oxidative deamination.
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25. Protein and Amino Acid Metabolism
Amino Acid Catabolism: Amino Group
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Amino Acid Catabolism: Amino Group practice set
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