Ch. 19 - Genetic Analysis of Quantitative Traits
Chapter 19, Problem 25
In human gestational development, abnormalities of the closure of the lower part of the mid-face can result in cleft lip, if the lip alone is affected by the closure defect, or in cleft lip and palate (the roof of the mouth), if the closure defect is more extensive. Cleft lip and cleft lip with cleft palate are multifactorial disorders that are threshold traits. A family with a history of either condition has a significantly increased chance of a recurrence of mid-face cleft disorder in comparison with families without such a history. However, the recurrence risk of a mid-face cleft disorder is higher in families with a history of cleft lip with cleft palate than in families with a history of cleft lip alone. Construct a similar explanation of why the recurrence risk of a cleft disorder is higher in families with a history of cleft lip with cleft palate than in families with a history of cleft lip alone.
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