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Ch. 26 - Population and Evolutionary Genetics
Chapter 25, Problem 15

Describe how populations with substantial genetic differences can form. What is the role of natural selection?

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Start by understanding that populations with substantial genetic differences can form through a process called speciation, which is the evolutionary process by which populations evolve to become distinct species.
Recognize that genetic differences can accumulate in populations due to various mechanisms such as mutation, genetic drift, gene flow, and natural selection.
Consider the role of natural selection, which acts on heritable traits that affect an organism's fitness, leading to the adaptation of populations to their environments. Over time, this can result in significant genetic differences between populations.
Explore how geographic isolation can contribute to genetic divergence. When populations are separated by physical barriers, they may experience different selective pressures and accumulate genetic differences independently.
Understand that reproductive isolation is a key factor in the formation of new species. As genetic differences accumulate, they can lead to the development of barriers to reproduction, such as behavioral differences or incompatible reproductive structures, further solidifying the genetic divergence between populations.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Genetic Drift

Genetic drift refers to the random fluctuations in allele frequencies within a population, which can lead to significant genetic differences over time, especially in small populations. This process can result in the loss of genetic variation and the fixation of certain alleles, contributing to the divergence of populations.
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Natural Selection

Natural selection is the process by which individuals with advantageous traits are more likely to survive and reproduce, leading to the gradual adaptation of populations to their environments. This mechanism can drive genetic differences as certain traits become more common in a population, influencing its evolutionary trajectory.
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Isolation Mechanisms

Isolation mechanisms, such as geographic, temporal, or behavioral isolation, prevent gene flow between populations. When populations are isolated, they can evolve independently, leading to the accumulation of genetic differences and potentially resulting in speciation over time.
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Related Practice
Textbook Question

Under what circumstances might a lethal dominant allele persist in a population?

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Textbook Question

Assume that a recessive autosomal disorder occurs in 1 of 10,000 individuals (0.0001) in the general population and that in this population about 2 percent (0.02) of the individuals are carriers for the disorder. Estimate the probability of this disorder occurring in the offspring of a marriage between first cousins. Compare this probability to the population at large.

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Textbook Question

One of the first Mendelian traits identified in humans was a dominant condition known as brachydactyly. This gene causes an abnormal shortening of the fingers or toes (or both). At the time, some researchers thought that the dominant trait would spread until 75 percent of the population would be affected (because the phenotypic ratio of dominant to recessive is 3 : 1). Show that the reasoning was incorrect.

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Textbook Question

Achondroplasia is a dominant trait that causes a characteristic form of dwarfism. In a survey of 50,000 births, five infants with achondroplasia were identified. Three of the affected infants had affected parents, while two had normal parents. Calculate the mutation rate for achondroplasia and express the rate as the number of mutant genes per given number of gametes.

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Textbook Question

A recent study examining the mutation rates of 5669 mammalian genes (17,208 sequences) indicates that, contrary to popular belief, mutation rates among lineages with vastly different generation lengths and physiological attributes are remarkably constant [Kumar, S., and Subramanian, S. (2002). Proc. Natl. Acad. Sci. USA 99:803–808]. The average rate is estimated at 12.2×10⁻⁹ per bp per year. What is the significance of this finding in terms of mammalian evolution?

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Textbook Question

What are considered significant factors in maintaining the surprisingly high levels of genetic variation in natural populations?

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