Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
7. DNA and Chromosome Structure
Alternative DNA Forms
2:23 minutes
Problem 34
Textbook Question
Textbook QuestionDNA and RNA are chemically very similar but are distinguished, in large part, by the presence of a 2'-OH group in RNA and a 2'-H group in DNA. Why do you suppose that both DNA and RNA have 3'-OH groups and we do not typically find nucleic acids within cells that have 3'-H groups?
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Nucleotide Structure
Nucleotides, the building blocks of DNA and RNA, consist of a sugar, a phosphate group, and a nitrogenous base. The sugar in RNA is ribose, which contains a hydroxyl (–OH) group at the 2' position, while DNA has deoxyribose, which lacks this group. This structural difference is crucial for the stability and function of each nucleic acid.
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3'-OH Group Functionality
The 3'-OH group in nucleic acids is essential for the formation of phosphodiester bonds, which link nucleotides together to form the backbone of DNA and RNA. This hydroxyl group allows for the addition of new nucleotides during DNA replication and RNA transcription, making it vital for the synthesis and integrity of genetic material.
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Chemical Stability and Reactivity
The presence of a 2'-OH group in RNA makes it more reactive and less stable than DNA, which can lead to RNA's shorter lifespan in cells. Conversely, the 2'-H group in DNA contributes to its stability, allowing it to serve as a long-term storage form of genetic information. This stability is crucial for the preservation of genetic material across generations.
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