A man, J.B., has a sister with autosomal recessive galactosemia (OMIM 230400), and his partner, S.B., has a brother with galactosemia. Galactosemia is a serious condition caused by an enzyme deficiency that prevents the metabolism of the sugar galactose. Neither J.B. nor S.B. has galactosemia, but they are concerned about the risk that a future child of theirs will have the condition. What is the probability their first child will have galactosemia?
Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
2. Mendel's Laws of Inheritance
Probability and Genetics
2:26 minutes
Problem 39bKlug - 12th Edition
Textbook Question
Textbook QuestionA geneticist from an alien planet that prohibits genetic research brought with him to Earth two pure-breeding lines of frogs. One line croaks by uttering 'rib-it rib-it' and has purple eyes. The other line croaks more softly by muttering 'knee-deep knee-deep' and has green eyes. With a newfound freedom of inquiry, the geneticist mated the two types of frogs, producing F₁ frogs that were all utterers and had blue eyes. A large F₂ generation then yielded the following ratios: 27/64 blue-eyed, 'rib-it' utterer 12/64 green-eyed, 'rib-it' utterer 9/64 blue-eyed, 'knee-deep' mutterer 9/64 purple-eyed, 'rib-it' utterer 4/64 green-eyed, 'knee-deep' mutterer 3/64 purple-eyed, 'knee-deep' mutterer One set of crosses with his true-breeding lines initially caused the geneticist some confusion. When he crossed true-breeding purple-eyed, 'knee-deep' mutterers with true-breeding green-eyed, 'knee-deep' mutterers, he often got different results. In some matings, all offspring were blue-eyed, 'knee-deep' mutterers, but in other matings all offspring were purple-eyed, 'knee-deep' mutterers. In still a third mating, 1/2 blue-eyed, 'knee-deep' mutterers and 1/2 purple-eyed, 'knee-deep' mutterers were observed. Explain why the results differed.
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